BiochemistrybioRxiv
Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression
J. Zhao, V. DiGiacomo, M. Ferreras-Gutierrez…·M. Garcia-Marcos
This study introduces IGGi-11, a small-molecule inhibitor that blocks non-canonical G-protein signaling by disrupting GIV/Girdin interaction, inhibiting cancer metastasis without affecting canonical GPCR signaling.
DOI 10.1073/pnas.2213140120