Author

J.-C. Park

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Luebbers· 3 shared M. Garcia-Marcos· 3 shared J. Zhao· 2 shared A. Beeler· 1 shared A. I. de Opakua· 1 shared A. Semeano· 1 shared A. Torres· 1 shared C. E. Philibert· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

A. Luebbers

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

R. Janicot, M. Maziarz, J.-C. Park, A. Luebbers, E. Green, J. Zhao, C. E. Philibert, H. Zhang, M. D. Layne, J. C. Wu, M. Garcia-Marcos

The paper develops a biosensor platform to measure GPCR activity in various contexts, revealing insights into coupling selectivity, pharmacogenomics, and signaling bias.

Cell · Mar 1, 2024Peer-reviewedBiochemistry

Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G-protein subunits

J.-C. Park, A. Luebbers, M. Dao, A. Semeano, M. P. Papakonstantinou, S. Broselid, H. Yano, K. Martemyanov, M. Garcia-Marcos

The paper shows how GINIP biases GPCR signaling to favor Gβγ over G signaling, preventing neurotransmission imbalances and seizure susceptibility.

bioRxiv · Mar 3, 2023Biochemistry

Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression

J. Zhao, V. DiGiacomo, M. Ferreras-Gutierrez, S. Dastjerdi, A. I. de Opakua, J.-C. Park, A. Luebbers, Q. Chen, A. Beeler, F. J. Blanco, M. Garcia-Marcos

This study introduces IGGi-11, a small-molecule inhibitor that blocks non-canonical G-protein signaling by disrupting GIV/Girdin interaction, inhibiting cancer metastasis without affecting canonical GPCR signaling.

bioRxiv · Feb 18, 2023Biochemistry

NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and suppresses PDAC initiation

i. Cobo, S. Paliwal, J. Melia-Aloma, A. Torres, J. Martinez-Villarreal, F. Garcia, I. Millan, N. del Pozo, J.-C. Park, R. J. MacDonald, J. Munoz, F. X. Real

This study identifies NFIC as a regulator of acinar cell differentiation and ER stress, showing its role in suppressing pancreatic ductal adenocarcinoma initiation.

bioRxiv · Aug 9, 2021 · PreprintCell Biology