Author

A. I. Marcus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Approach:deep learning· 1

Frequent Co-Authors

C.-S. Seong· 2 shared H. Claussen· 2 shared H. Fu· 2 shared H. R. Johnston· 2 shared J. K. Mouw· 2 shared J. Koo· 2 shared M. Gilbert-Ross· 2 shared S. S. Ramalingam· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

C.-S. Seong

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Author profile →

4 papers

Recent·Most cited

Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer

J. Koo, C.-S. Seong, R. E. Parker, B. Dwivedi, R. A. Arthur, A. R. Dinasarapu, H. R. Johnston, H. Claussen, C. Tucker-Burden, S. S. Ramalingam, H. Fu, W. Zhou, A. I. Marcus, M. Gilbert-Ross

This study identifies the ALK2/BMP6 iron homeostasis pathway as a therapeutic target in LKB1-mutant lung cancer using live-cell imaging and transcriptome analysis.

bioRxiv · Jun 14, 2023 · PreprintCancer Biology

A live-cell platform to isolate phenotypically defined subpopulations for spatial multi-omic profiling

T. O. Khatib, A. M. Amanso, B. Pedro, C. M. Knippler, E. R. Summerbell, N. M. Zohbi, J. M. Konen, J. K. Mouw, A. I. Marcus

bioRxiv · Feb 28, 2023 · PreprintCell Biology

Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.

C.-S. Seong, C. Huang, A. C. Boese, Y. Hou, J. Koo, J. K. Mouw, M. Rupji, G. Joseph, H. R. Johnston, H. Claussen, J. M. Switchenko, M. Behera, M. Churchman, J. M. Kolesar, S. M. Arnold, , M. Gilbert-Ross

The paper shows that loss of HD-PTP, a tumor suppressor, promotes RAS-driven oncogenesis and is associated with adenosquamous lung cancer, suggesting it as a therapeutic target.

bioRxiv · Jan 26, 2023 · PreprintCancer Biology

The Complex Ecosystem in Non Small Cell Lung Cancer Invasion

S. Haney, J. Konen, A. I. Marcus, M. Bazhenov

The paper develops a computational model of lung cancer ecosystems to explore how subclone interactions influence invasion, finding that signaling environment manipulations can alter tumor dynamics and invasive potential.

PLOS Computational Biology · May 24, 2018Peer-reviewedCancer Biology