Author

J. Koo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. I. Marcus· 2 shared C.-S. Seong· 2 shared H. Claussen· 2 shared H. Fu· 2 shared H. R. Johnston· 2 shared M. Gilbert-Ross· 2 shared S. S. Ramalingam· 2 shared W. Zhou· 2 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. I. Marcus

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Author profile →

3 papers

Recent·Most cited

Robust data-driven segmentation of pulsatile cerebral vessels using functional magnetic resonance imaging

A. M. Wright, T. Xu, J. Ingram, J. Koo, Y. Zhao, Y. Tong, Q. Wen

This study develops an automatic method to segment cerebral arteries and superior sagittal sinus from fMRI data, showing high reproducibility across age groups.

bioRxiv · Jul 17, 2024Bioengineering

Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer

J. Koo, C.-S. Seong, R. E. Parker, B. Dwivedi, R. A. Arthur, A. R. Dinasarapu, H. R. Johnston, H. Claussen, C. Tucker-Burden, S. S. Ramalingam, H. Fu, W. Zhou, A. I. Marcus, M. Gilbert-Ross

This study identifies the ALK2/BMP6 iron homeostasis pathway as a therapeutic target in LKB1-mutant lung cancer using live-cell imaging and transcriptome analysis.

bioRxiv · Jun 14, 2023 · PreprintCancer Biology

Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.

C.-S. Seong, C. Huang, A. C. Boese, Y. Hou, J. Koo, J. K. Mouw, M. Rupji, G. Joseph, H. R. Johnston, H. Claussen, J. M. Switchenko, M. Behera, M. Churchman, J. M. Kolesar, S. M. Arnold, , M. Gilbert-Ross

The paper shows that loss of HD-PTP, a tumor suppressor, promotes RAS-driven oncogenesis and is associated with adenosquamous lung cancer, suggesting it as a therapeutic target.

bioRxiv · Jan 26, 2023 · PreprintCancer Biology