Castration-resistant prostate cancer: Androgen receptor inactivation induces telomere DNA damage, and damage response inhibition leads to cell death
V. Reddy, A. Iskander, C. Hwang, G. Divine, M. Menon, E. R. Barrack, G. P.-v. Reddy, S.-H. Kim
This study shows that combining an AR antagonist with an ATM inhibitor induces telomere DNA damage and DDR inhibition, leading to cell death in CRPC cells.
bioRxiv · Jan 9, 2019Cancer Biology