Twinfilin is a non-processive depolymerase which synergizes with formin to dramatically accelerate actin filament uncapping by 300-fold
bioRxiv · Jul 19, 2024 · PreprintBiochemistry
Author
V. Reddy
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Biology Disciplines
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2019-2024 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 8 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
An Azapeptide Platform in Conjunction with Covalent Warheads to Uncover High-Potency Inhibitors for SARS-CoV-2 Main Protease
K. Khatua, Y. R. Alugubelli, K. Yang, V. Reddy, L. Blankenship, D. Coleman, S. Atla, S. Chaki, Z. Geng, X. Ma, J. Xiao, P.-H. Chen, C.-C. Cho, E. C. Vatansever, Y. Ma, , W. R. Liu
This study develops an azapeptide platform with covalent warheads to identify potent SARS-CoV-2 MPro inhibitors, including MPI89 with a 10 nM EC50 and high selectivity.
bioRxiv · Apr 11, 2023 · PreprintBiochemistry
Phenotyping of lymphoproliferative tumours generated in xenografts of non-small cell lung cancer
D. R. Pearce, A. U. Akarca, R. P. H. De Maeyer, E. Kostina, A. Huebner, M. Sivakumar, T. Karasaki, K. Shah, S. M. Janes, N. E. McGranahan, V. Reddy, A. Akbar, D. A. Moore, T. Marafioti, C. Swanton, R. E. Hynds
The paper identifies lymphoproliferative B cells in NSCLC PDX models and develops a tool for generating pathology overview figures.
bioRxiv · Jan 24, 2023Cancer Biology
Genome-wide Disease Screening in Early Human Embryos with Primary Template-Directed Amplification
Y. Xia, V. Gonzales-Pena, D. Klein, J. Luquette, L. Puzon, N. Siddiqui, V. Reddy, P. Park, B. Behr, C. Gawad
This paper introduces a method to screen early human embryos for genetic variants using primary template-directed amplification, identifying aneuploidy, mitochondrial variants, and disease-causing mutations, and computing polygenic risk scores.
bioRxiv · Jul 6, 2021 · PreprintBioengineering
Castration-resistant prostate cancer: Androgen receptor inactivation induces telomere DNA damage, and damage response inhibition leads to cell death
V. Reddy, A. Iskander, C. Hwang, G. Divine, M. Menon, E. R. Barrack, G. P.-v. Reddy, S.-H. Kim
This study shows that combining an AR antagonist with an ATM inhibitor induces telomere DNA damage and DDR inhibition, leading to cell death in CRPC cells.
bioRxiv · Jan 9, 2019Cancer Biology