A. J. Brinkworth

Chlamydia trachomatis modulates the expression of JAK-STAT signaling components to attenuate the Type II interferon response of epithelial cells

This study shows Chlamydia trachomatis reduces JAK-STAT pathway components to dampen IFN-gamma signaling in epithelial cells.

Chlamydia trachomatis induces the transcriptional activity of host YAP in a Hippo-independent fashion

This study shows Chlamydia trachomatis activates host YAP transcriptional activity independently of the Hippo pathway, leading to altered gene expression and potential therapeutic targets.

The iron-dependent repressor YtgR regulates the tryptophan salvage pathway through a bipartite mechanism of transcriptional control in Chlamydia trachomatis

The paper identifies how YtgR, an iron-dependent regulator in Chlamydia trachomatis, controls the tryptophan salvage pathway through dual transcriptional repression and termination mechanisms under iron starvation.

Genome-wide transcriptional responses of iron-starved Chlamydia trachomatis reveal prioritization of metabolic precursor synthesis over protein translation

This paper identifies the immediate transcriptional response of Chlamydia trachomatis to iron starvation, showing prioritization of metabolic precursor synthesis over protein translation.