N. D. Pokorzynski

Host cell amplification of nutritional stress contributes to persistence in Chlamydia trachomatis

This study shows that host cell suppression of GTP biosynthesis amplifies nutritional stress, inducing Chlamydia trachomatis persistence under iron or tryptophan starvation.

Regulation of an iron-dependent repressor by tryptophan availability attenuates transcription of the tryptophan salvage genes in Chlamydia trachomatis

The paper shows that YtgR represses trpBA expression in Chlamydia trachomatis by sensing both iron and tryptophan levels, using a rare triple-tryptophan motif to regulate transcription termination.

The iron-dependent repressor YtgR regulates the tryptophan salvage pathway through a bipartite mechanism of transcriptional control in Chlamydia trachomatis

The paper identifies how YtgR, an iron-dependent regulator in Chlamydia trachomatis, controls the tryptophan salvage pathway through dual transcriptional repression and termination mechanisms under iron starvation.