Cell BiologybioRxivPreprint
SNTA1 GeneRescues Ion Channel Function in Cardiomyocytes Derived from Induced Pluripotent Stem Cells Reprogrammed from Muscular Dystrophy Patients with Arrhythmias
J. Jalife, E. N. Jimenez-Vazquez, M. Arad…·D. E. Michele
This study shows that iPSC-CMs from DMD patients with arrhythmias have NaV1.5-Kir2.1 channelosome dysfunction, which can be rescued by 1-syntrophin.
DOI 10.1101/2022.01.25.477696