Thrombospondin-1 promotes fibro-adipogenic stromal expansion and contractile dysfunction of the diaphragm in obesity
E. D. Buras, M.-S. Woo, R. K. Verma, S. H. Kondisetti, C. S. Davis, D. R. Claflin, K. Converso-Baran, D. E. Michele, S. V. Brooks, T.-H. Chun
This study shows that THBS1 promotes diaphragm stromal expansion and contractile dysfunction in obesity by driving FAP proliferation and ECM changes.
bioRxiv · Aug 17, 2023Cell Biology