Author

A. J. Dear

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

G. Meisl· 2 shared S. LinseiD· 2 shared T. P. Knowles· 2 shared C. K. Xu· 1 shared D. Clow· 1 shared E. Andrzejewska· 1 shared G. Krainer· 1 shared J. Habchi· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

G. Meisl

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2 papers

Recent·Most cited

Molecular mechanism of α-synuclein aggregation on lipid membranes revealed.

A. J. Dear, X. Teng, S. R. Ball, J. Lewin, R. I. Horne, D. Clow, N. Harper, K. Yahya, T. C. Michaels, S. Linse, T. P. Knowles, X. Yang, S. C. Brewerton, J. Thomson, J. Habchi, G. Meisl

This study reveals that lipids promote α-synuclein aggregation by enabling elongation, using a kinetic model to describe the co-aggregation process in vitro.

bioRxiv · Oct 20, 2023Biophysics

α-Synuclein oligomers form by secondary nucleation

C. K. Xu, G. Meisl, E. Andrzejewska, G. Krainer, A. J. Dear, M. C. Cruz, S. Turi, R. Jacquat, W. E. Arter, M. Vendruscolo, S. Linse, T. P. Knowles

This study shows α-synuclein oligomers form via secondary nucleation on fibril surfaces, not from monomers, and this process is enhanced by agitation under physiological conditions.

bioRxiv · May 28, 2023Biophysics