Author

E. Andrzejewska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

M. Vendruscolo· 2 shared A. Aubert· 1 shared A. J. Dear· 1 shared A. Possenti· 1 shared A. Srivastava· 1 shared B. Caughey· 1 shared B. Ghetti· 1 shared C. K. Xu· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

M. Vendruscolo

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2 papers

Recent·Most cited

α-Synuclein oligomers form by secondary nucleation

C. K. Xu, G. Meisl, E. Andrzejewska, G. Krainer, A. J. Dear, M. C. Cruz, S. Turi, R. Jacquat, W. E. Arter, M. Vendruscolo, S. Linse, T. P. Knowles

This study shows α-synuclein oligomers form via secondary nucleation on fibril surfaces, not from monomers, and this process is enhanced by agitation under physiological conditions.

bioRxiv · May 28, 2023Biophysics

Discovery of Potent Inhibitors of α-Synuclein Aggregation Using Structure-Based Iterative Learning

R. I. Horne, E. Andrzejewska, P. Alam, Z. F. Brotzakis, A. Srivastava, A. Aubert, M. Nowinska, R. C. Gregory, R. Staats, A. Possenti, S. Chia, P. Sormanni, B. Ghetti, B. Caughey, T. P. J. Knowles, M. Vendruscolo

This paper uses structure-based machine learning to identify potent small molecule inhibitors of α-synuclein aggregation, achieving compounds two orders of magnitude more potent than previous reports.

bioRxiv · Nov 10, 2021Biophysics