Author

A. J. Macadam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

H. Fox· 3 shared K. Grehan· 3 shared N. J. Stonehouse· 3 shared C. Porta· 2 shared D. I. Stuart· 2 shared D. J. Rowlands· 2 shared E. E. Fry· 2 shared L. Sherry· 2 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

H. Fox

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Risk-free polio vaccine: Recombinant expression systems for production of stabilised virus-like particles

L. Sherry, M. W. Bahar, C. Porta, H. Fox, K. Grehan, V. Nasta, H. M. Duyvesteyn, L. de Colibus, J. Marsian, I. Murdoch, D. Ponndorf, S.-R. Kim, S. Shah, S. Carlyle, J. J. Swanson, , D. J. Rowlands

This study produces stabilized poliovirus VLPs using recombinant systems, showing equivalent or better immunogenicity than current vaccines.

bioRxiv · May 13, 2024 · PreprintMicrobiology

Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate.

N. J. Kingston, J. S. Snowden, A. Martyna, M. Shegdar, K. Grehan, A. Tedcastle, E. Pegg, H. Fox, A. J. Macadam, J. Martin, J. M. Hogle, D. Rowlands, N. J. Stonehouse

This study produces antigenically stable EVA71 virus-like particles in Pichia pastoris, showing they retain native antigenic conformation and elicit neutralising antibodies comparable to inactivated virus vaccines.

bioRxiv · Jan 30, 2023 · PreprintImmunology

A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation

M. W. Bahar, V. Nasta, H. Fox, L. Sherry, K. Grehan, C. Porta, A. J. Macadam, N. J. Stonehouse, D. J. Rowlands, E. E. Fry, D. I. Stuart

This study identifies a conserved glutathione binding site in poliovirus VLPs that can be targeted by antivirals and used to stabilize vaccines.

bioRxiv · Sep 8, 2022Biochemistry