D. J. Rowlands

Risk-free polio vaccine: Recombinant expression systems for production of stabilised virus-like particles

This study produces stabilized poliovirus VLPs using recombinant systems, showing equivalent or better immunogenicity than current vaccines.

Amino acid substitutions in norovirus VP1 dictate cell tropism via an attachment process dependent on membrane mobility.

This study identifies an amino acid substitution in norovirus VP1 that enhances cellular attachment and alters tropism by affecting receptor recruitment and membrane mobility.

Development of Enterovirus anti-viral agents that target the viral 2C protein

This study develops broad-spectrum anti-viral compounds targeting the conserved EV 2C protein, showing low IC50 values and suggesting a role for 2C in capsid assembly.

Protease-independent production of poliovirus virus-like particles in Pichia pastoris: Implications for efficient vaccine development and insights into capsid assembly.

This study produces protease-independent poliovirus VLPs in Pichia pastoris, showing they maintain native antigenicity and thermostability, suggesting potential for improved vaccine development.

A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation

This study identifies a conserved glutathione binding site in poliovirus VLPs that can be targeted by antivirals and used to stabilize vaccines.

VelcroVax: a bolt-on vaccine platform technology improves antibody titres against a viral glycoprotein in mice

VelcroVax is a vaccine platform that enhances antibody titres against a viral glycoprotein in mice by combining a modified VLP with a SUMO-tagged antigen.

Structural insight into Pichia pastoris fatty acid synthase

The paper determines the structure of P. pastoris fatty acid synthase using cryoEM, identifying structural differences from S. cerevisiae FAS and resolving the mobile ACP domain.