Author

A. J. Vecchio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1 Assay:structural biology· 1

Frequent Co-Authors

A. A. Kossiakoff· 2 shared P. K. Dominik· 2 shared S. K. Erramilli· 2 shared B. J. Orlando· 1 shared C. Ogbu· 1 shared C. P. Ogbu· 1 shared S. Roy· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

A. A. Kossiakoff

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2 papers

Recent·Most cited

Cryo-EM structures of a synthetic antibody against 22 kDa claudin-4 reveal its complex with Clostridium perfringens enterotoxin

S. K. Erramilli, P. K. Dominik, C. P. Ogbu, A. A. Kossiakoff, A. J. Vecchio

This paper uses cryo-EM to determine the structure of a synthetic antibody complex with claudin-4 and CpE, revealing binding mechanisms and subtype selectivity.

bioRxiv · Jun 12, 2023 · PreprintBiophysics

Development, Structure, and Mechanism of Synthetic Antibodies that Target Claudin and Clostridium perfringens Enterotoxin Complexes

B. J. Orlando, P. K. Dominik, S. Roy, C. Ogbu, S. K. Erramilli, A. A. Kossiakoff, A. J. Vecchio

This paper develops synthetic antibodies (sFabs) targeting claudin-4 and Clostridium perfringens enterotoxin (CpE) complexes, revealing their binding mechanisms and structural insights to inform therapeutic strategies.

bioRxiv · Jan 1, 2022Biophysics