Development, Structure, and Mechanism of Synthetic Antibodies that Target Claudin and Clostridium perfringens Enterotoxin Complexes
B. J. Orlando, P. K. Dominik, S. Roy, C. Ogbu, S. K. Erramilli, A. A. Kossiakoff, A. J. Vecchio
This paper develops synthetic antibodies (sFabs) targeting claudin-4 and Clostridium perfringens enterotoxin (CpE) complexes, revealing their binding mechanisms and structural insights to inform therapeutic strategies.
bioRxiv · Jan 1, 2022Biophysics