Author

S. K. Erramilli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:protein structure prediction· 3 Assay:structural biology· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

A. A. Kossiakoff· 5 shared P. K. Dominik· 3 shared A. J. Vecchio· 2 shared A. K. Kossiakoff· 1 shared A. R. Reckers· 1 shared B. C. Choy· 1 shared B. G. Reddy· 1 shared B. J. Orlando· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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5 shared papersBiochemistry

A. A. Kossiakoff

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Author profile →

6 papers

Recent·Most cited

Structural and molecular basis of choline uptake into the brain by FLVCR2

R. J. Cater, D. Mukherjee, E. Gil Iturbe, S. K. Erramilli, T. Chen, K. Koo, N. G. Santander, A. R. Reckers, B. Kloss, T. Gawda, B. C. Choy, Z. Zhang, O. B. Clarke, S. W. Yee, A. K. Kossiakoff, , F. Mancia

This study identifies FLVCR2 as the primary choline transporter at the blood-brain barrier, determines its structures, and elucidates its mechanism of choline uptake.

bioRxiv · Oct 5, 2023Biochemistry

Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding

P. P. Knejski, S. K. Erramilli, A. A. Kossiakoff

The paper determines the cryo-EM structure of P. aeruginosa PhuR bound to heme, revealing the role of Y529 in iron coordination and providing insights for developing conformation-specific antibodies.

bioRxiv · Aug 1, 2023 · PreprintBiochemistry

Cryo-EM structures of a synthetic antibody against 22 kDa claudin-4 reveal its complex with Clostridium perfringens enterotoxin

S. K. Erramilli, P. K. Dominik, C. P. Ogbu, A. A. Kossiakoff, A. J. Vecchio

This paper uses cryo-EM to determine the structure of a synthetic antibody complex with claudin-4 and CpE, revealing binding mechanisms and subtype selectivity.

bioRxiv · Jun 12, 2023 · PreprintBiophysics

Conformation-specific synthetic antibodies discriminate multiple functional states of the ion channel CorA

S. K. Erramilli, P. K. Dominik, D. Deneka, P. P. Tokarz, S. S. Kim, B. G. Reddy, B. M. Skrobek, O. Dalmas, E. Perozo, A. A. Kossiakoff

This study uses synthetic antibodies to identify and characterize different conformational states of the CorA ion channel under varying magnesium conditions.

bioRxiv · May 7, 2023Biochemistry

Development, Structure, and Mechanism of Synthetic Antibodies that Target Claudin and Clostridium perfringens Enterotoxin Complexes

B. J. Orlando, P. K. Dominik, S. Roy, C. Ogbu, S. K. Erramilli, A. A. Kossiakoff, A. J. Vecchio

This paper develops synthetic antibodies (sFabs) targeting claudin-4 and Clostridium perfringens enterotoxin (CpE) complexes, revealing their binding mechanisms and structural insights to inform therapeutic strategies.

bioRxiv · Jan 1, 2022Biophysics

K29-Linked Ubiquitin Signaling Regulates Proteotoxic Stress Response and Cell Cycle

Y. Yu, Q. Zheng, S. K. Erramilli, M. Pan, S. Park, Y. Xie, J. Li, J. Fei, A. A. Kossiakoff, L. Liu, M. Zhao

This study identifies sAB-K29, a tool to detect K29-linked polyubiquitin, and shows its role in proteotoxic stress response and cell cycle regulation.

bioRxiv · Oct 15, 2020Cell Biology