Author

A. J. Zaug

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Assay:imaging· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

T. R. Cech· 4 shared C. J. Lim· 2 shared D. S. Wuttke· 2 shared A. E. McKay· 1 shared A. G. Jimenez· 1 shared A. T. Barbour· 1 shared C. L. Olson· 1 shared E. Edelson· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

T. R. Cech

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq

N. M. Forino, J. Z. Woo, A. J. Zaug, A. G. Jimenez, E. Edelson, T. R. Cech, S. Rouskin, M. Stone

This study identifies a misfolded CR4/5 conformation in hTR that is not required for hTERT binding and is detrimental to telomerase activity.

bioRxiv · Oct 4, 2023Biochemistry

CST does not evict elongating telomerase but prevents initiation by ssDNA binding

A. J. Zaug, C. J. Lim, C. L. Olson, M. T. Carilli, K. J. Goodrich, D. S. Wuttke, T. R. Cech

The paper investigates CST's role in telomerase inhibition and shows it does not terminate ongoing telomerase extension but prevents initiation through ssDNA binding.

Nucleic Acids Research · Oct 28, 2021Peer-reviewedBiochemistry

The cryo-EM structure of human CST reveals a two-megadalton decameric assembly bound to telomeric DNA

C. J. Lim, A. T. Barbour, A. J. Zaug, A. E. McKay, D. S. Wuttke, T. R. Cech

The paper reports the cryo-EM structure of human CST bound to telomeric DNA, revealing a decameric supercomplex and providing insights into CST function and disease associations.

bioRxiv · Oct 23, 2019Biophysics

Dynamics of human telomerase recruitment depend on template-telomere base-pairing

J. C. Schmidt, A. J. Zaug, R. Kufer, T. R. Cech

This study uses live-cell imaging to show that telomerase recruitment depends on DNA base-pairing and processivity in human cells.

bioRxiv · Nov 10, 2017Cell Biology