Author

J. C. Schmidt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Ecology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 8 Approach:experimental assay· 8 Organism:human· 6 Assay:imaging· 5 Approach:microscopy & imaging analysis· 4 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

D. Broadbent· 3 shared C. Barnaba· 2 shared D. G. Broadbent· 2 shared E. M. Patrick· 2 shared G. I. Perez· 2 shared J. R. Heyza· 2 shared M. Mikhova· 2 shared A. B. Hanker· 1 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersCell Biology

D. Broadbent

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Declining reservoir elevations following a two-decade drought increase water temperatures and non-native fish passage facilitating a downstream invasion

D. E. Eppehimer, C. B. Yackulic, L. A. Bruckerhoff, J. Wang, K. L. Young, K. R. Bestgen, B. A. Mihalevich, J. C. Schmidt

The paper models how declining reservoir levels and warming temperatures in the Colorado River facilitated non-native smallmouth bass invasion and reproduction.

bioRxiv · Jan 23, 2024Ecology

Pharmacogenomics Guided Spaceflight: the intersection between space-flown drugs and space genes

T. M. Nelson, J. K. Rose, C. E. Walter, G. L. Cervantes-Navarro, C. M. Schmidt, R. Lin, E. Alexander, J. T. Zheng, B. S. Glicksberg, J. C. Schmidt, E. Overbey, B. Rana, H. Patel, M. A. Schmidt, C. E. Mason

This paper creates a database of space-flown drugs and identifies spaceflight-related gene targets to advance pharmacogenomics for space missions.

bioRxiv · Jan 16, 2024 · PreprintPharmacology & Toxicology

The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy

D. G. Broadbent, C. M. McEwan, T.-M. Tsang, D. M. Poole, B. C. Naylor, J. C. Price, J. C. Schmidt, J. L. Andersen

This study identifies poly-ubiquitin as a signal recruiting ATG9A to initiate basal autophagy by mediating autophagy foci assembly.

bioRxiv · Nov 28, 2023 · PreprintCell Biology

AMPK Regulates Phagophore-to-Autophagosome Maturation

C. Barnaba, D. G. Broadbent, G. I. Perez, J. C. Schmidt

This study shows that AMPK inhibits phagophore tethering to donor membranes during glucose starvation, slowing autophagosome maturation.

bioRxiv · Sep 28, 2023Cell Biology

Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells

M. Mikhova, T. Janovic, N. J. Goff, J. R. Heyza, K. Meek, J. C. Schmidt

This study uses live cell single-molecule imaging to analyze NHEJ complex dynamics, revealing stepwise maturation and defining NHEJ repair capacity in vivo.

bioRxiv · Jun 22, 2023Cell Biology

Systematic Analysis of Autophagy Identifies Atg9 Vesicles as the Origin of the Phagophore

D. Broadbent, C. Barnaba, J. C. Schmidt

The paper systematically analyzes autophagy factors in human cells to show that ATG9 vesicles initiate phagophores and that ATG2-mediated tethering is critical for their maturation.

bioRxiv · Aug 3, 2022 · PreprintCell Biology

Systematic analysis of the molecular and biophysical properties of key DNA damage response factors

J. R. Heyza, M. Mikhova, A. Bahl, D. Broadbent, J. C. Schmidt

The paper uses single-molecule imaging to analyze the biophysical properties and recruitment dynamics of DNA damage response factors in living cells.

bioRxiv · Jun 9, 2022Cell Biology

TCAB1 prevents nucleolar accumulation of the telomerase RNA to promote telomerase assembly

B. S. Al-Masraf, G. I. Perez, E. M. Patrick, K. Adams-Boone, S. B. Cohen, L. Han, K. Yu, J. C. Schmidt

This study shows that TCAB1 prevents telomerase RNA from accumulating in the nucleolus, which is necessary for telomerase assembly.

bioRxiv · May 27, 2021 · PreprintCell Biology

BRAF inhibitor resistance confers increased sensitivity to mitotic inhibitors

S. Misek, T. Dexheimer, M. Akram, S. E. Conrad, J. C. Schmidt, R. R. Neubig, K. A. Gallo

This study identifies that BRAF inhibitor-resistant melanoma cells are more sensitive to mitotic inhibitors, revealing a potential therapeutic strategy for resistant tumors.

bioRxiv · Apr 15, 2021Cancer Biology

A Versatile Oblique Plane Microscope for Large-Scale and High-Resolution Imaging of Subcellular Dynamics.

E. Sapoznik, B.-J. Chang, J. Huh, R. J. Ju, E. Azarova, T. Pohlkamp, E. S. Welf, D. Broadbent, A. F. Carisey, S. J. Stehbens, K.-m. Lee, A. Marin, A. B. Hanker, J. C. Schmidt, C. L. Arteaga, , R. P. Fiolka

This paper introduces an improved oblique plane microscope with enhanced resolution and usability, demonstrating its application in imaging various subcellular dynamics and challenging biological phenomena.

bioRxiv · Apr 7, 2020Biophysics

Mechanism of processive telomerase catalysis revealed by high-resolution optical tweezers

E. M. Patrick, J. Slivka, B. Payne, M. J. Comstock, J. C. Schmidt

This study uses optical tweezers to show how telomerase binds DNA and synthesizes telomeric repeats, revealing the mechanism of processive telomerase catalysis.

bioRxiv · Aug 23, 2019Biochemistry

Dynamics of human telomerase recruitment depend on template-telomere base-pairing

J. C. Schmidt, A. J. Zaug, R. Kufer, T. R. Cech

This study uses live-cell imaging to show that telomerase recruitment depends on DNA base-pairing and processivity in human cells.

bioRxiv · Nov 10, 2017Cell Biology