Author

A. K. Drelich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

C.-T. K. Tseng· 2 shared B. M. Judy· 1 shared B. Sankaran· 1 shared B. Zhao· 1 shared B.-H. Peng· 1 shared C. A. Fierke· 1 shared D. A. Scott· 1 shared E. C. Vatansever· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

C.-T. K. Tseng

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2 papers

Recent·Most cited

Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection

A. K. Drelich, K. Rayavara, J. Hsu, P. Saenkham-Huntsinger, B. M. Judy, V. Tat, T. G. Ksiazek, B.-H. Peng, C.-T. K. Tseng

This study characterizes the coagulopathy in AC70 hACE2 transgenic mice infected with SARS-CoV-2, revealing hypercoagulable states and ANXA2 system dysregulation.

bioRxiv · Oct 30, 2023Microbiology

A Speedy Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors

W. R. Liu, K. S. Yang, X. R. Ma, Y. Ma, Y. R. Alugubelli, D. A. Scott, E. C. Vatansever, A. K. Drelich, Z. Z. Geng, L. R. Blankenship, B. Sankaran, H. E. Ward, Y. J. Sheng, J. C. Hsu, K. K. Kratch, , H. S. Hayatshahi

This study designs and synthesizes potent SARS-CoV-2 main protease inhibitors, with some showing IC50 values below 100 nM and high virus inhibition potency in cell assays.

bioRxiv · Jul 28, 2020 · PreprintBiochemistry