B. Zhao

A Radiomic Approach to Clinical MRI Refines the Thalamus-Cognition Link in Multiple Sclerosis

This study uses radiomic features from thalamic nuclei to identify associations with cognitive performance in multiple sclerosis patients, finding radiomic features outperform volumetric measures.

Inducing aggresome and stable tau aggregation in Neuro2a cells with an optogenetic tool.

This paper introduces OptoTau, an optogenetic tool that induces different tau aggregation forms in Neuro2a cells based on blue light exposure patterns.

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

This study uses spatial multi-omics to compare EBV-positive and EBV-negative cHL, identifying distinct TME features and immunological signatures linked to EBV.

Histone acetyltransferase HAF2 associates with PDC to control H3K14ac and H3K23ac in ethylene response

This study identifies HAF2 as a histone acetyltransferase that interacts with EIN2-C and PDC to regulate H3K14ac and H3K23ac in response to ethylene.

Effects of Prospective Motion Correction on Perivascular Spaces at 7T MRI Evaluated Using Motion Artifact Simulation

This study evaluates prospective motion correction's effect on perivascular space visibility using motion artifact simulation in MRI data.

Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

This study shows that inhibiting OGT activates type I interferon-dependent antitumor immunity by enhancing the cGAS-STING pathway through genomic instability.

Xanthomonas euvesicatoria effector XeAvrRxo1 triggers a Rxo1-mediated defense response in Nicotiana benthamiana and its chaperone Xe4429 functions as an antitoxin, an expression repressor, and an enhancer of XeAvrRxo1 secretion

This study identifies XeAvrRxo1 as a virulence and avirulence effector in X. euvesicatoria and shows that its chaperone Xe4429 suppresses toxicity, represses expression, and enhances secretion of XeAvrRxo1.

Autophagy regulates tumor growth and metastasis

This study shows that autophagy inhibition stabilizes Twist1 via p62, promoting tumor growth and metastasis in skin and melanoma models.

Biosynthesis of H-GDGTs linked to ocean oxygen deficiency

The paper identifies the gene responsible for biosynthesizing H-GDGTs and shows its association with oxygen-deficient environments.

Self-assembly vascularized human cardiac organoids model cardiac diseases in petri dishes and in mice

This study generates self-assembling cardiac organoids from human pluripotent stem cells to model myocardial infarction and SARS-CoV-2 fibrosis, showing in vitro and in vivo disease characteristics and vascular integration.

Structure of Orthoreovirus RNA Chaperone σNS, a Component of Viral Replication Factories

This paper determines the structure of the reovirus σNS RNA chaperone and shows how its oligomeric state and N-terminal arm regulate RNA binding and chaperone activity.

Resolution enhancement with deblurring by pixel reassignment (DPR)

This paper introduces a deblurring algorithm that improves spatial resolution in fluorescence microscopy by avoiding noise-amplification and preserving local linearity.

Levy statistics define anxiety and depression in mice subjected to chronic stress

This paper identifies Levy statistics as a marker for anxiety and depression in mice under chronic stress, using movement patterns and machine learning for classification.

Evolution of Shewanella oneidensis MR-1 in competition with Citrobacter freundii

This study examines how Shewanella oneidensis MR-1 evolves in competition with Citrobacter freundii An1 under different electron acceptor conditions.

RBP-J regulates homeostasis and function of circulating Ly6C lo monocytes

This study shows RBP-J regulates blood Ly6Clo monocytes and their derived lung macrophages by controlling CCR2 expression.

An Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the Mechanism of Danbai Granules in Treating Sequelae of Pelvic Inflammatory Disease

Comparative transcriptome revealed potential genes related with drug resistance in Melanoma

The paper identifies SENP1 and Hippo signaling pathway activation as factors contributing to drug resistance in melanoma using transcriptomic and functional analyses.

Target Recycling Amplification Process for Digital Detection of Exosomal MicroRNAs Through Photonic Resonator Absorption Microscopy

This paper introduces TRAP, a method for detecting exosomal miRNAs with high sensitivity and selectivity, showing improved detection limits compared to qRT-PCR.

The direct interaction with transcriptional factor TEAD4 implied a straightforward regulation mechanism of tumor suppressor NF2

This study identifies a direct interaction between NF2 and TEAD4, showing NF2 inhibits TEAD4 stability and function, revealing a new mechanism of NF2's tumor suppressor role via the Hippo pathway.

Monitoring the intestinal magnetic field with optically pumped atomic magnetometers

This study uses optically pumped magnetometers to measure the intestinal magnetic field of a rabbit, showing their potential for noninvasive disease detection.

Genetic Dissection of Mutual Interference between Two Consecutively Learned Tasks in Drosophila

This study identifies distinct molecular mechanisms for proactive and retroactive interference in Drosophila during consecutive learning tasks.

Evolution of spatial and temporal cis-regulatory divergence between marine and freshwater sticklebacks

This study identifies cis-regulatory divergence between marine and freshwater sticklebacks using allele-specific expression in hybrids, showing widespread regulatory changes and lineage-specific selection.

Oligomeric polymorphism of HIV-1 Vpu protein in lipid environment and in solution

This study investigates the oligomeric structures of HIV-1 Vpu protein in solution and lipid environments, revealing novel forms and environmental effects on oligomer stability.

Development of molecular markers of the KTI mutant alleles generated by CRISPR/Cas9-mediated mutagenesis in soybean

This study develops molecular markers for KTI mutant alleles in soybean using CRISPR/Cas9 to aid in breeding low TI trait cultivars.

A comprehensive single cell data analysis of in lymphoblastoid cells reveals the role of Super-enhancers in maintaining EBV latency

This study uses scRNA-seq to analyze EBV latency in lymphoblastoid cells, identifying two distinct clusters with different EBV gene expression and revealing the role of super-enhancers in maintaining latency.

Low photosynthetic rate under low light stress inhibited sucrose distribution and transportation to grain

This study shows low light stress reduces summer maize yield by decreasing leaf photosynthetic rate, impairing sucrose transport to grains, and creating a sugar concentration gradient that inhibits sucrose output.

A multispecific antibody prevents immune escape and confers pan-SARS-CoV-2 neutralization

This paper develops multispecific antibodies that neutralize all SARS-CoV-2 variants, including Omicron, by targeting multiple epitopes on the spike protein.

Bone marrow AdipoQ-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis and bone mass

The paper identifies bone marrow AdipoQ-lineage progenitors as a major source of M-CSF, showing their critical role in macrophage development, osteoclastogenesis, and bone mass regulation.

The energy landscape reshaped by strain-specific mutations underlies the long-range epistasis in NS1 evolution of influenza A virus

The paper investigates how strain-specific mutations in the NS1 protein of influenza A virus reshape the energy landscape, leading to long-range epistasis.

Phosphorylation Status of B beta Subunit Acts as a Switch to Regulate the Function of Phosphatase PP2A in Ethylene-mediated Root Growth Inhibition

The paper shows that phosphorylation of Bβ subunit of PP2A acts as a switch to regulate PP2A activity, controlling EIR1 phosphorylation and auxin transport to modulate ethylene-mediated root growth inhibition.