xbx-4, a homolog of the Joubert syndrome gene FAM149B1, acts via the CCRK and MAK kinase cascade to regulate cilia morphology
This study identifies XBX-4 as a regulator of the CCRK/MAK kinase pathway in C. elegans, showing it controls cilia morphology and that mutations in its DUF3719 domain cause ciliary elongation.
bioRxiv · May 9, 2021Cell Biology