Author

A. Karunarathne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

W. Thotamune· 3 shared D. Wijayaratna· 2 shared M. Tennakoon· 2 shared S. Ubeysinghe· 2 shared A. Terakita· 1 shared D. Kankanamge· 1 shared F. Fanelli· 1 shared F. Sacchetta· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

W. Thotamune

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Author profile →

4 papers

Recent·Most cited

Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling

W. Thotamune, S. Ubeysinghe, K. K. Shrestha, M. E. Mostafa, M. C. Young, A. Karunarathne

This paper introduces OptoIso, a photo-labile ligand that selectively activates βAR signaling at the cell surface or endomembranes using blue light, enabling precise study of its role in cardiac pathology.

bioRxiv · Feb 14, 2024Biochemistry

Engineered blue-shifted melanopsins for subcellular optogenetics

D. Wijayaratna, F. Sacchetta, L. Pedraza Gonzalez, F. Fanelli, T. Sugihara, M. Koyanagi, S. Piyawardana, K. Ghotra, W. Thotamune, A. Terakita, M. Olivucci, A. Karunarathne

This paper engineers blue-shifted melanopsin mutants using computational methods to enable subcellular optogenetic control without red light activation.

bioRxiv · Oct 7, 2023 · PreprintBiochemistry

CaaX-motif adjacent residues control G protein prenylation under suboptimal conditions

M. Tennakoon, W. Thotamune, J. L. Payton, A. Karunarathne

The paper investigates how specific residues near the CaaX-motif regulate G protein prenylation and membrane interactions under suboptimal conditions, explaining differential statin effects on G protein signaling.

bioRxiv · Jul 4, 2023 · PreprintCell Biology

Molecular regulation of GPCR-G-protein-governed PIP3 generation and its adaptation

D. Wijayaratna, K. Ratnayake, S. Ubeysinghe, D. Kankanamge, M. Tennakoon, A. Karunarathne

The paper investigates how GPCR activation leads to PIP3 generation and its temporal regulation through G protein subunit-dependent adaptation.

bioRxiv · Aug 31, 2022 · PreprintCell Biology