A. Kolovou

Post-correlation on-lamella cryo-CLEM reveals the membrane architecture of lamellar bodies

The paper uses cryo-CLEM to study lamellar bodies in their unperturbed state, revealing their membrane architecture and a new outer membrane dome protein complex.

Alpha-synuclein fibrils induce autophagy in microglial cells as a consequence of lysosomal damage.

This study shows that alpha-synuclein fibrils cause lysosomal damage and autophagy in microglial cells, leading to mitochondrial dysfunction and cell death.