Alpha-synuclein fibrils induce autophagy in microglial cells as a consequence of lysosomal damage.
C. Bussi, J. M. Peralta Ramos, D. S. Arroyo, J. I. Gallea, P. Ronchi, A. Kolovou, J. M. Wang, O. Florey, M. S. Celej, Y. Schwab, N. T. Ktistakis, P. Iribarren
This study shows that alpha-synuclein fibrils cause lysosomal damage and autophagy in microglial cells, leading to mitochondrial dysfunction and cell death.
bioRxiv · Jul 27, 2017Cell Biology