O. Florey

Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via CASM

The paper identifies a direct ATG8 conjugation response to lysosome damage, distinct from lysophagy, involving ATG2 and lipid transfer.

V-ATPase is a universal regulator of LC3 associated phagocytosis and non-canonical autophagy

This study identifies V-ATPase as a universal regulator of LC3-associated phagocytosis and non-canonical autophagy, showing its role in CASM activation and its disruption by Salmonella SopF.

De novo identification of universal cell mechanics gene signatures

This study identifies a conserved gene module involved in cell mechanics regulation using a mechanomics approach combining mechanical characterization and machine learning analysis of transcriptomic data.

GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis

Subtractive CRISPR screen identifies factors involved in non-canonical LC3 lipidation.

The paper uses a subtractive CRISPR screen to identify factors involved in non-canonical LC3 lipidation, revealing distinct roles for ATG4D and the RALGAP complex in different contexts.

Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine

This study shows that during non-canonical autophagy, ATG8 proteins are conjugated to phosphatidylserine instead of phosphatidylethanolamine, revealing a distinct lipidation mechanism.

Alpha-synuclein fibrils induce autophagy in microglial cells as a consequence of lysosomal damage.

This study shows that alpha-synuclein fibrils cause lysosomal damage and autophagy in microglial cells, leading to mitochondrial dysfunction and cell death.