Separating distinct structures of multiple macromolecular assemblies from cryo-EM projections
E. J. Verbeke, Y. Zhou, A. P. Horton, A. L. Mallam, D. W. Taylor, E. M. Marcotte
The paper develops a method to separate distinct macromolecular structures from heterogeneous cryo-EM data by using common lines in a graphical framework, enabling ab initio 3D structure reconstruction without stringent purification.
bioRxiv · Apr 30, 2019Biochemistry