A. Lanna

Disruptors of sestrin-MAPK interactions rejuvenate T cells and expand TCR specificity

This paper develops DOS, a first-in-class disruptor of sestrin-MAPK complexes, which rejuvenates senescent T cells and expands TCR specificity by generating new T cell clones.

Intercellular telomere transfer extends T cell lifespan

The paper shows T cells extend telomeres by acquiring telomere vesicles from APCs, independent of telomerase, thereby increasing their lifespan.