Author

B. Vaz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. N. Singh· 2 shared I. Torrecilla· 2 shared K. Ramadan· 2 shared M. Popovic· 2 shared A. Akbar· 1 shared A. Kiltie· 1 shared A. Lanna· 1 shared A. Rodriguez De Lera· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

A. N. Singh

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Synthesis and pharmacological characterization of UVI3502, a novel cannabinoid receptor 1 (CB1) antagonist/inverse agonist

I. Bengoetxea de Tena, G. Pereira-Castelo, J. Martinez-Gardeazabal, M. Moreno-Rodriguez, I. Manuel, C. Martinez, B. Vaz, J. Gonzalez-Ricarte, R. Alvarez, A. Torres-Mozas, F. Peccati, G. Jimenez Oses, A. Rodriguez De Lera, R. Rodriguez-Puertas

This paper synthesizes and characterizes UVI3502, a novel CB1 receptor antagonist/inverse agonist, showing high affinity for CB1 and low affinity for CB2, with potential interactions with GPR55.

bioRxiv · Jun 14, 2024 · PreprintPharmacology & Toxicology

Intercellular telomere transfer extends T cell lifespan

B. Vaz, C. Vuotto, S. Valvo, C. D'Ambra, F. M. Esposito, V. Chiurchiu, O. Devine, M. Sanchez, G. Borsellino, D. Gilroy, A. Akbar, M. Dustin, M. Karin, A. Lanna

The paper shows T cells extend telomeres by acquiring telomere vesicles from APCs, independent of telomerase, thereby increasing their lifespan.

bioRxiv · Oct 9, 2020 · PreprintImmunology

SPRTN protease and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

B. Vaz, A. Ruggiano, M. Popovic, G. Rodriguez-Berriguete, S. Kilgas, A. N. Singh, I. Torrecilla, G. Higgins, A. Kiltie, K. Ramadan

This study identifies SUMO-1 modification of DNA-protein crosslinks (DPCs) as a mechanism that promotes SPRTN proteolysis over homologous recombination, preventing genomic instability.

bioRxiv · Feb 14, 2020 · PreprintCell Biology

SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication

S. Halder, I. Torrecilla, M. Burkhalter, M. Popovic, J. Fielden, B. Vaz, J. Oehler, D. Pilger, D. Lessel, K. Wiseman, A. N. Singh, I. Vendrell, R. Fischer, M. Philipp, K. Ramadan

This paper shows SPRTN protease and CHK1 form a cross-activation loop to protect DNA replication from stress by regulating CHK1 chromatin eviction and DPC removal.

bioRxiv · Oct 31, 2018Cell Biology