S. Valvo

Thrombospondins 1 and 4 undergo coordinated transport to multicore cytotoxic granules to regulate SMAP biogenesis and function in CTL-mediatedcytotoxicity

This study shows TSP-4 is required for TSP-1 association with lytic granules and SMAP-mediated cytotoxicity in CTLs, and its expression is suppressed in CLL cell supernatants.

Phosphatases of regenerating liver balance F-actin rearrangements during T cell activation through WD repeat containing protein 1

This study shows that PRLs regulate F-actin dynamics during T cell activation by interacting with WDR1, affecting IS formation and cytokine production.

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency

The paper evaluates TcE formats to determine how contact distance and flexibility affect their potency in forming immunological synapses.

Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse through distinct adaptors

The paper shows clathrin mediates TCR internalization and vesicular release at the immunological synapse through distinct adaptors HRS/STAM2 and EPN1.

Synthetic antigen presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses.

This study uses synthetic antigen-presenting cells to analyze the composition and functional specialization of extracellular vesicles released during T cell immunological synapses.

Intercellular telomere transfer extends T cell lifespan

The paper shows T cells extend telomeres by acquiring telomere vesicles from APCs, independent of telomerase, thereby increasing their lifespan.

In silico characterization of mechanisms positioning costimulatory and checkpoint complexes in immune synapses

The paper uses computer simulations to reveal how immunoglobulin superfamily adhesion and costimulatory/checkpoint complexes are localized in immunological synapses.

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

This study shows Sema3A inhibits tumor-specific CD8+ T cell function by inducing cytoskeletal paralysis via NRP1 in the tumor microenvironment.

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T-cells

The paper identifies synaptic ectosomes released by helper T cells that contain TCR and CD40L, enabling dendritic cell maturation and cytokine production.

CD2 expression acts as a quantitative checkpoint for immunological synapse structure and T-cell activation.

The paper shows CD2 expression levels determine immunological synapse structure and T-cell activation by influencing CD2-CD58 localization and Src-family kinase recruitment.