Substrate stiffness facilitates improved induced pluripotent stem cell production through modulation of both early and late phases of cell reprogramming
M. M. Chowdhury, S. Samuel Zimmerman, H. Leeson, C. Nefzger, J. C. Mar, A. Laslett, J. M. Polo, E. J. Wolvetang, J. J. Cooper-White
This study shows that medium stiffness substrates enhance iPSC production by improving both early and late reprogramming phases, leading to higher numbers and better quality iPSCs.
bioRxiv · Feb 27, 2023 · PreprintBioengineering