Author

A. Liakopoulos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

D. E. Rozen· 2 shared D. Rozen· 2 shared J. G. C. van Hasselt· 2 shared L. B. S. Aulin· 2 shared C. Du· 1 shared C. Nagel· 1 shared D. Claessen· 1 shared E. Fragkiskou· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

D. E. Rozen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Design principles of collateral sensitivity-based dosing strategies

L. B. S. Aulin, A. Liakopoulos, P. H. van der Graaf, D. E. Rozen, J. G. C. van Hasselt

This study uses mathematical modeling to identify design principles for collateral sensitivity-based antibiotic treatment strategies that can suppress resistance.

bioRxiv · Mar 31, 2021Pharmacology & Toxicology

Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone-resistance evolution

A. Liakopoulos, L. B. S. Aulin, M. Buffoni, E. Fragkiskou, J. G. C. van Hasselt, D. E. Rozen

The paper measures collateral and fitness effects of fluoroquinolone resistance alleles in Streptococcus pneumoniae and shows how allelic identity influences resistance evolution dynamics.

bioRxiv · Oct 19, 2020 · PreprintMicrobiology

Manganese complex Br increases antibiotic sensitivity in multidrug resistant Streptococcus pneumoniae

A. Liakopoulos, R. LaRagione, C. Nagel, U. Schatzschneider, D. Rozen, J. W. Betts

This study shows that the Mn complex [Mn(CO)3(tpa-κ3N)]Br increases antibiotic sensitivity in multidrug-resistant Streptococcus pneumoniae in vitro and in vivo.

bioRxiv · Feb 27, 2020Microbiology

Antibiotic production in Streptomyces is organized by a division of labour through terminal genomic differentiation

Z. Zhang, C. Du, F. de Barsy, M. Liem, A. Liakopoulos, G. van Wezel, Y. H. Choi, D. Claessen, D. Rozen

The paper shows that Streptomyces coelicolor colonies use division of labour to enhance antibiotic production by generating specialized mutants that trade individual fitness for increased secondary metabolite diversity and yield.

bioRxiv · Jun 28, 2019Evolutionary Biology