Author

D. E. Rozen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Evolutionary Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 4 Approach:statistical model· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Liakopoulos· 2 shared G. P. van Wezel· 2 shared J. G. C. van Hasselt· 2 shared L. B. S. Aulin· 2 shared S. Westhoff· 2 shared A. Kloosterman· 1 shared A. P. Roberts· 1 shared A. Swinkels· 1 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Liakopoulos

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Evolution of genome fragility enables microbial division of labor

E. S. Colizzi, B. van Dijk, R. M. H. Merks, D. E. Rozen, R. M. Vroomans

This paper shows that genome architecture evolves to enable mutation-driven division of labor in bacteria by separating growth and antibiotic genes with fragile sites.

bioRxiv · Jun 4, 2021Evolutionary Biology

Design principles of collateral sensitivity-based dosing strategies

L. B. S. Aulin, A. Liakopoulos, P. H. van der Graaf, D. E. Rozen, J. G. C. van Hasselt

This study uses mathematical modeling to identify design principles for collateral sensitivity-based antibiotic treatment strategies that can suppress resistance.

bioRxiv · Mar 31, 2021Pharmacology & Toxicology

Competition sensing alters antibiotic production in Streptomyces

S. Westhoff, A. Kloosterman, S. F. A. van Hoesel, G. P. van Wezel, D. E. Rozen

This study shows that Streptomyces produce antibiotics more when competing with closely related strains or those sharing biosynthetic pathways, but not when threatened by toxins, and often reduce production under resource limitation.

mBio · Feb 23, 2021Peer-reviewedMicrobiology

Mutational meltdown of microbial altruists in Streptomyces coelicolor colonies

Z. Zhang, S. Shitut, B. Claushuis, D. Claessen, D. E. Rozen

The paper shows altruistic mutant cells in Streptomyces coelicolor experience mutational meltdown due to genomic deletions and increased mutation rates, leading to reduced fitness and sterility.

bioRxiv · Oct 20, 2020Evolutionary Biology

Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone-resistance evolution

A. Liakopoulos, L. B. S. Aulin, M. Buffoni, E. Fragkiskou, J. G. C. van Hasselt, D. E. Rozen

The paper measures collateral and fitness effects of fluoroquinolone resistance alleles in Streptococcus pneumoniae and shows how allelic identity influences resistance evolution dynamics.

bioRxiv · Oct 19, 2020 · PreprintMicrobiology

Spatial structure increases the benefits of antibiotic production in Streptomyces griseus

S. Westhoff, S. B. Otto, A. Swinkels, B. Bode, G. P. van Wezel, D. E. Rozen

This study shows that spatial structure enhances the fitness benefits of streptomycin production in S. griseus by reducing invasion thresholds and enabling competition against susceptible strains.

bioRxiv · Nov 29, 2018Microbiology

Conserved collateral susceptibility networks in diverse clinical strains of Escherichia coli.

N. L. Podnecky, E. G. Fredheim, J. Kloos, V. Sorum, R. Primicerio, A. P. Roberts, D. E. Rozen, O. Samuelsen, P. J. Johnsen

The paper examines collateral susceptibility networks in diverse E. coli strains to inform antimicrobial resistance treatment strategies.

bioRxiv · Jan 17, 2018Microbiology