Age-associated repression of HNF4α is a driver and potential therapeutic target in liver metabolic dysfunction
Jessica Proulx, K. A. Lande, X. Lei, A. P. Havas, M. Garcia Teneche, A. Rajesh, H. Tanaka, M. A. LaPorta, G. Evensen, S. Mamde, L. Wang, A. Gandhi, R. Arnold, A. Davis, A. Liou, , P. D. Adams
This study identifies age-associated repression of HNF4α as a driver of liver metabolic dysfunction and shows that restoring HNF4α can reverse some age-related liver defects.
bioRxiv · Nov 9, 2026 · PreprintMolecular Biology