A. Gandhi

Age-associated repression of HNF4α is a driver and potential therapeutic target in liver metabolic dysfunction

This study identifies age-associated repression of HNF4α as a driver of liver metabolic dysfunction and shows that restoring HNF4α can reverse some age-related liver defects.

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death

This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.

CORK1, a LRR-Malectin Receptor Kinase for Cellooligomer Perception in Arabidopsis thaliana

This study identifies CORK1 as a receptor kinase in Arabidopsis that detects cellulose breakdown products, triggering Ca2+-dependent responses and immune-related signaling.

Homeostatic control of c-di-AMP synthase (MsDisA) and hydrolase (MsPDE) from Mycobacterium smegmatis

This study characterizes the c-di-AMP synthase (MsDisA) and hydrolase (MsPDE) from M. smegmatis under different pH and osmolytic conditions, revealing their biochemical and structural regulation in response to environmental stress.

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium

This study identifies key residues and structural dynamics governing the monomer-dimer equilibrium of hCEACAM1 using biophysical and structural methods.

JAK Inhibitors Suppress Colon Cancer Cachexia-Associated Anorexia and Adipose Wasting in Mice

This study shows JAK inhibitors reduce cachexia-associated anorexia and adipose wasting in colon cancer models by blocking cytokine-induced pathways.