H. Tanaka

Age-associated repression of HNF4α is a driver and potential therapeutic target in liver metabolic dysfunction

This study identifies age-associated repression of HNF4α as a driver of liver metabolic dysfunction and shows that restoring HNF4α can reverse some age-related liver defects.

Genome sequence and cell biological toolbox of the highly regenerative, coenocytic green feather alga Bryopsis

This paper presents the genome sequence of Bryopsis, a coenocytic green alga, and identifies gene duplications and unique features that may underlie its regeneration ability.

Raman microscopy of cryofixed biological specimens for high-resolution and high-sensitivity chemical imaging

This study improves Raman microscopy's signal-to-noise ratio and resolution by imaging cryofixed biological specimens, enabling high-content chemical imaging under physiological conditions.

A Practical Approach for Targeting Structural Variants Genome-wide in Plasma Cell-free DNA

The paper introduces GAPF-seq, a method to detect structural variants in cfDNA, achieving high accuracy in distinguishing tumors from controls.

Entropic interfacial charge separation suppresses coarsening of nanoscale condensates

The paper identifies an entropic charge separation mechanism that limits coarsening in nanoscale condensates, explaining their long-term stability.

Time-deterministic cryo-optical microscopy

The paper introduces a technique to rapidly freeze biological systems during optical observation, enabling detailed time-specific analysis of cellular dynamics at high spatial resolution.

Delayed SARS-CoV-2 Spread and Olfactory Cell Lineage Impairment in Close-Contact Infection Syrian Hamster Models

This study investigates SARS-CoV-2 transmission via close contact in Syrian hamsters and shows delayed olfactory cell lineage damage compared to direct infection.

Development of two microbial source tracking markers for detection of wastewater-associated Escherichia coli isolates

This study identifies two microbial source tracking markers, W_nqrC and W_clsA_2, for detecting wastewater-associated E. coli isolates, showing higher performance than existing markers.

Conserved Transcription Factors Control Chromatin Accessibility and Gene Expression to Maintain Cell Fate Stability and Restrict Reprogramming of Differentiated Cells

This study identifies four conserved transcription factors that oppose cell fate reprogramming by controlling chromatin accessibility and gene expression, and shows their potential as therapeutic targets for regenerative medicine.

Hydrodynamics of gliding penguin flipper suggests the adjustment of sweepback with swimming speeds

This study uses CFD simulations to analyze how sweepback angles of penguin flippers affect hydrodynamic performance at different swimming speeds.

Effects of green manure application on soil microbial communities and activities in the decontaminated sandy soil paddy field in Fukushima, Japan

This study examines how green manure decomposition affects soil microbial communities and enzyme activities in a decontaminated sandy soil paddy field in Fukushima, Japan.

Combined landscape of single-nucleotide variants and copy-number alterations in clonal hematopoiesis

The paper combines SNVs/indels and CNAs analysis in CH to show their co-occurrence and impact on health outcomes.

Synaptojanin1 deficiency upregulates basal level autophagosome formation in astrocytes

This study shows Synaptojanin1 deficiency increases basal autophagosome formation in astrocytes, with implications for Parkinsonism.

A lexical approach for identifying behavioral action sequences

This paper introduces BASS, an algorithm that identifies rare behavioral action sequences in sequential data, demonstrating its effectiveness in zebrafish and glider simulations.

Quantitative detection of sleep apnea with wearable watch device

This study uses PPG data from a wearable watch and the ACAT algorithm to detect sleep apnea, finding a strong correlation between CVHR frequency and AHI.

Host-dependent fungus-fungus competition suppresses fungal pathogenesis in Arabidopsis thaliana

The paper shows that a non-pathogenic fungus inhibits pathogenic fungi in Arabidopsis roots, depending on host phosphate status and defense mechanisms.

Development of locomotion in low water exposure using sturgeon

This study investigates sturgeon locomotion in low water conditions, finding that they exhibit behavioural adaptations similar to escape responses, improving their mobility through trunk-twisting actions.

Rapid bacterial identification by direct PCR amplification of 16S rRNA genes using the MinION™ nanopore sequencer

This study develops a rapid bacterial identification method using MinION sequencing and direct PCR of 16S rRNA genes, improving diagnostic speed and accuracy.

Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis

This study shows peroxisomes regulate mitochondrial dynamics and apoptosis by affecting Drp1-mediated fission and caspase activation.

Cleaner wrasse pass the mark test. What are the implications for consciousness and self-awareness testing in animals?

This paper shows cleaner wrasse fish pass all phases of the mirror mark test, challenging the interpretation of the test as a measure of self-awareness in animals.

Propofol induces metabolic reprogramming and cell death in a mitochondrial electron transport chain-dependent manner

This study shows propofol causes metabolic reprogramming and cell death by impairing mitochondrial function, specifically complexes I and III, and this effect is exacerbated by preexisting mitochondrial dysfunction.