Author

A. Lkharrazi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Fraefel· 3 shared B. Vogt· 2 shared E. M. Schraner· 2 shared H. Büning· 2 shared K. Tobler· 2 shared S. O. Sutter· 2 shared A. F. Meier· 1 shared C. Ros· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

C. Fraefel

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The interferon-γ inducible factor 16 (IFI16) restricts adeno-associated virus serotype 2 (AAV2) transduction in an immune-modulatory independent way

S. O. Sutter, K. Tobler, M. Seyffert, A. Lkharrazi, J. Zöllig, E. M. Schraner, B. Vogt, H. Büning, C. Fraefel

The paper identifies IFI16 as a restriction factor for AAV2 transduction that acts independently of immune modulation by interfering with Sp1-dependent promoter activation.

bioRxiv · Jan 22, 2024 · PreprintMicrobiology

Non-canonical induction of autophagy increases adeno-associated virus type 2 (AAV2) transduction efficiency

S. O. Sutter, S. Jetzer, A. Lkharrazi, S. Pedersen, E. M. Schraner, B. Vogt, H. Büning, C. Fraefel

The paper shows that inducing autophagy with hyperosmotic sucrose enhances AAV2 transduction efficiency through a non-canonical pathway, distinct from the PI3K-III-dependent mechanism.

bioRxiv · Jan 8, 2024 · PreprintMicrobiology

Herpes Simplex Virus Co-Infection Facilitates Rolling Circle Replication of the Adeno-Associated Virus Genome

A. F. Meier, K. Tobler, R. Leisi, A. Lkharrazi, C. Ros, C. Fraefel

This study shows HSV-1 supports AAV genome replication via rolling circle replication, contrasting the traditional rolling hairpin model, using nanopore sequencing for analysis.

bioRxiv · Dec 23, 2020Microbiology