KSHV promotes oncogenic FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation
V. Majerciak, B. Alvarado-Hernandez, Y. Ma, S. Duduskar, A. Lobanov, M. Cam, Z.-M. Zheng
This study identifies KSHV ORF57 as a viral RNA-binding protein that stabilizes FOS RNA, inhibits AEN, and transactivates RGS2 to promote AKT phosphorylation during lytic infection.
mBio · Jan 8, 2025Peer-reviewedMicrobiology