Z.-M. Zheng

KSHV promotes oncogenic FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation

This study identifies KSHV ORF57 as a viral RNA-binding protein that stabilizes FOS RNA, inhibits AEN, and transactivates RGS2 to promote AKT phosphorylation during lytic infection.

The lnc-FANCI-2 intrinsically restricts RAS signaling in HPV16-infected cervical cancer

This study identifies lnc-FANCI-2 as a regulator of RAS signaling in HPV16-infected cervical cancer, showing its role in lesion progression and patient survival.

Rational design by structural biology of industrializable, long-acting antihyperglycemic GLP-1 receptor agonists

The paper designs long-acting GLP-1 receptor agonists using structural biology to prevent DPP-4 degradation while maintaining receptor binding, achieving hypoglycemic effects lasting over 24 hours.

Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57

This study identifies ORF57's role in regulating KSHV RNA splicing, revealing its impact on viral gene expression and immune evasion during lytic infection.

RNA helicase DDX6 in P-bodies is essential for the assembly of stress granules

This study shows DDX6 in P-bodies is essential for stress granule assembly, with its helicase activity suppressing stress granule formation in normal cells.

Human papillomavirus type 16 circular RNA is barely detectable for the claimed transformation activity

The paper challenges the claim that HPV16 circular RNA circE7 drives cell transformation, showing its low abundance and attributing observed effects to off-target siRNA effects on linear E7 mRNAs.

Expression of HPV oncogenes from a single integration site in cervical cancer cell lines

The paper identifies that HPV oncogenes are expressed from a single integration site in cervical cancer cell lines, revealing mechanisms of viral-host fusion transcript production and their impact on cell growth.

Papillomavirus can be transmitted through the blood and produce infections in blood recipients: Evidence from two animal models

This paper shows that papillomavirus can be transmitted through blood and cause infections in animal models, suggesting blood transfusion as a potential route for HPV infection and cancer in humans.