Author

L. A. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. A. Aguilar· 4 shared S. V. Brooks· 4 shared J. A. Castor-Macias· 3 shared J. F. Markworth· 3 shared J. Larouche· 3 shared C. Davis· 2 shared E. Lim· 2 shared K. R. Maddipati· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCell Biology

C. A. Aguilar

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling

S. W. S. Kang, R. P. Cunningham, C. B. Miller, L. A. Brown, C. M. Cultraro, A. Harned, K. Narayan, J. Hernandez, L. M. Jenkins, A. Lobanov, M. Cam, N. Porat-Shliom

The paper investigates mitochondrial heterogeneity in the liver by combining spatial proteomics and functional analysis, revealing distinct metabolic functions in periportal and pericentral regions.

bioRxiv · Apr 13, 2023Cell Biology

Sestrins regulate age-induced deterioration of muscle stem cell homeostasis

B. A. Yang, J. A. Castor-Macias, P. M. Fraczek, L. A. Brown, M. Kim, S. V. Brooks, J. H. Lee, C. A. Aguilar

This study shows that Sestrins maintain muscle stem cell quiescence and function by regulating mTORC1 signaling and metabolism, and their loss accelerates age-related deterioration.

bioRxiv · Dec 15, 2020Cell Biology

Lipidomic Profiling Reveals an Age-Related Deficiency of Skeletal Muscle Proresolving Mediators that Contributes to Maladaptive Tissue Remodeling

J. F. Markworth, L. A. Brown, E. Lim, J. A. Castor-Macias, J. Larouche, P. C. D. Macpherson, C. Davis, C. A. Aguilar, K. R. Maddipati, S. V. Brooks

This study identifies age-related deficiencies in proresolving mediators in skeletal muscle, leading to impaired regeneration and inflammation, and shows that RvD1 treatment can mitigate some adverse effects.

bioRxiv · Nov 5, 2020Immunology

Immunoresolvents Support Skeletal Myofiber Regeneration via Actions on Myeloid and Muscle Stem Cells

J. F. Markworth, L. A. Brown, E. Lim, C. Floyd, J. Larouche, J. A. Castor-Macias, K. B. Sugg, D. C. Sarver, P. C. F. Macpherson, C. Davis, C. A. Aguilar, K. R. Maddipati, S. V. Brooks

This study shows that resolvin D1 promotes skeletal muscle regeneration by modulating myeloid cells and muscle stem cells, improving recovery without directly affecting myogenesis.

bioRxiv · Jun 12, 2020Immunology

Single Cell Deconstruction of Muscle Stem Cell Heterogeneity During Aging Reveals Sensitivity to the Neuromuscular Junction

P. J. Ulintz, J. Larouche, M. Mohiuddin, J. Castor Macias, S. J. Kurpiers, W. Liu, J. J. Choi, L. A. Brown, J. F. Markworth, K. de Silva, B. D. Levi, S. D. Merajver, J. V. Chakkalakal, Y. C. Jang, S. V. Brooks, C. A. Aguilar

The paper identifies a neuro-responsive subset of muscle stem cells that support neuromuscular junction integrity during aging and neurodegeneration.

bioRxiv · May 28, 2020Cell Biology