L. M. Jenkins

SMARCD1 is a "Goldilocks" metastasis modifier

The paper identifies Smarcd1 as a 'Goldilocks' metastasis modifier gene, showing that both high and low expression correlate with better clinical outcomes, while intermediate expression worsens survival in breast cancer.

The thiol methyltransferase activity of TMT1A (METTL7A) is conserved across species

This study shows that TMT1A's ability to methylate thiol-based HDAC inhibitors is conserved across species, suggesting its functional relevance in animal models.

YAP localization mediates mechanical adaptation of human cancer cells during extravasation in vivo

This study investigates how YAP-mediated mechanogenotypes influence mechanical adaptation of cancer cells during extravasation and organ colonization in vivo.

A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling

The paper investigates mitochondrial heterogeneity in the liver by combining spatial proteomics and functional analysis, revealing distinct metabolic functions in periportal and pericentral regions.

The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors

This study identifies METTL7A and METTL7B as methyltransferases that confer resistance to thiol-based HDAC inhibitors by modifying the drug's zinc-binding thiol.

Developmental Effects on Relative Use of PEPCK and NADP-ME Pathways of C4 Photosynthesis in Maize

This study examines how the proportion of two C4 pathways in maize depends on canopy position rather than leaf age.

Local RNA translation controls cell migration and Rab GTPase function

The paper shows that local RNA translation of RAB13 at cellular protrusions is required for full activation of the GTPase and efficient cell migration, mediated by its association with RABIF.

Shifting carbon flux from non-transient starch to lipid allows oil accumulation in transgenic tobacco leaves

This study shows that redirecting carbon from non-transient starch to lipid in tobacco leaves enables high oil accumulation through developmental source-sink plasticity.

Quantification and Discovery of Acyl-ACPs by LC-MS/MS

The paper develops a method to quantify acyl-ACPs at picogram levels and identifies new intermediates and acyl-ACPs, highlighting gaps in lipid metabolism understanding.

Melanoblast transcriptome analysis reveals novel pathways promoting melanoma metastasis

The paper analyzes the melanoblast transcriptome to identify genes involved in melanoma metastasis and discovers a 43-gene signature predictive of patient survival.