Author

A. M. Braxton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:deep learning· 4 Organism:human· 4 Assay:spatial transcriptomics· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:spatial domain detection· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. L. Kiemen· 4 shared D. Wirtz· 4 shared L. D. Wood· 4 shared R. H. Hruban· 4 shared P.-H. Wu· 3 shared T. C. Cornish· 3 shared A. C. Jiang· 2 shared A. Forjaz· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

A. L. Kiemen

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Author profile →

4 papers

Recent·Most cited

Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues

A. Forjaz, E. Vaz, V. M. Romero, S. Joshi, A. M. Braxton, A. C. Jiang, K. Fujikura, T. Cornish, S.-M. Hong, R. H. Hruban, P.-H. Wu, L. D. Wood, A. L. Kiemen, D. Wirtz

This study shows that 3D assessments are necessary to accurately determine tissue composition and neoplastic content, as 2D methods under-sample spatial heterogeneity.

bioRxiv · Dec 4, 2023Cancer Biology

Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings

A. L. Kiemen, P. Wu, A. M. Braxton, T. C. Cornish, R. H. Hruban, L. D. Wood, D. Wirtz, D. Zwicker

The paper uses AI-based 3D tissue mapping to show PanIN lesion sizes follow a power-law distribution and identifies growth mechanisms driving pancreatic cancer precursor lesions.

bioRxiv · Dec 1, 2023Biophysics

Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

A. M. Braxton, A. L. Kiemen, M. P. Grahn, A. Forjaz, J. M. Babu, L. Zheng, L. Jiang, H. Cheng, Q. Song, R. Reichel, S. Graham, A. I. Damanakis, C. G. Fischer, S. Mou, C. Metz, , L. D. Wood

This study uses 3D imaging and genomic analysis to show that human pancreatic precancerous lesions (PanINs) are highly multifocal and genetically heterogeneous.

bioRxiv · Jan 27, 2023 · PreprintCancer Biology

In situ characterization of the 3D microanatomy of the pancreas and pancreatic cancer at single cell resolution

A. L. Kiemen, A. M. Braxton, M. P. Grahn, K. S. Han, J. Mahesh Babu, R. Reichel, F. Amoa, S.-M. Hong, T. C. Cornish, E. D. Thompson, L. D. Wood, R. H. Hruban, P.-H. Wu, D. Wirtz

The paper develops a method to reconstruct 3D pancreatic tissue at single-cell resolution and maps cancer invasion modes in the tumor microenvironment.

bioRxiv · Dec 8, 2020Cancer Biology