Author

A. Forjaz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:clustering· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:deep learning· 2 Assay:proteomics· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

D. Wirtz· 5 shared P.-H. Wu· 5 shared A. L. Kiemen· 4 shared A. C. Jiang· 2 shared A. C. Johnston· 2 shared A. J. Crawford· 2 shared A. M. Braxton· 2 shared D. Kim· 2 shared

Activity by Year

2023-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersImmunology

D. Wirtz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

W. Du, B. Zhou, A. Forjaz, S. M. Shin, F. Wu, A. J. Crawford, P. R. Nair, A. C. Johnston, H. West-Foyle, A. Tang, D. Kim, R. Fan, A. L. Kiemen, P.-H. Wu, J. M. Phillip, , D. Wirtz

This study identifies high-motility tumor-associated monocytes (TAMos) that drive macrophage infiltration and cancer cell proliferation via IL-6 and MAPK pathways, suggesting IL-6 as a therapeutic target.

bioRxiv · Jul 16, 2024 · PreprintImmunology

Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

A. C. Johnston, G. M. Alicea, C. C. Lee, P. V. Patel, E. A. Hanna, E. Vaz, A. Forjaz, Z. Wan, P. R. Nair, Y. Lim, T. Chen, W. Du, D. Kim, T. D. Nichakawade, V. W. Rebecca, , D. Wirtz

This paper develops velocity receptors (VRs) to enhance CAR T cell migration through solid tumors, improving tumor infiltration and survival.

bioRxiv · Dec 13, 2023 · PreprintImmunology

Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues

A. Forjaz, E. Vaz, V. M. Romero, S. Joshi, A. M. Braxton, A. C. Jiang, K. Fujikura, T. Cornish, S.-M. Hong, R. H. Hruban, P.-H. Wu, L. D. Wood, A. L. Kiemen, D. Wirtz

This study shows that 3D assessments are necessary to accurately determine tissue composition and neoplastic content, as 2D methods under-sample spatial heterogeneity.

bioRxiv · Dec 4, 2023Cancer Biology

Precision-engineered biomimetics: the human fallopian tube

A. J. Crawford, A. Forjaz, I. Bhorkar, T. Roy, D. Schell, V. Queiroga, K. Ren, D. Kramer, J. Bons, W. Huang, G. C. Russo, M.-H. Lee, B. Schilling, P.-H. Wu, I.-M. Shih, , D. Wirtz

The paper develops a precision-engineered multi-compartment organoid model of the human fallopian tube validated against a 3D single-cell reference map.

bioRxiv · Jun 6, 2023 · PreprintBioengineering

Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

A. M. Braxton, A. L. Kiemen, M. P. Grahn, A. Forjaz, J. M. Babu, L. Zheng, L. Jiang, H. Cheng, Q. Song, R. Reichel, S. Graham, A. I. Damanakis, C. G. Fischer, S. Mou, C. Metz, , L. D. Wood

This study uses 3D imaging and genomic analysis to show that human pancreatic precancerous lesions (PanINs) are highly multifocal and genetically heterogeneous.

bioRxiv · Jan 27, 2023 · PreprintCancer Biology