Q. Song

The Intricate Relationship of G-Quadruplexes and Bacterial Pathogenicity Islands

This study analyzes G4 structures in bacterial pathogenicity islands and finds their non-random distribution and correlation with GC content, suggesting functional roles in DNA integration and pathogenicity.

Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathway

This study shows estrogen prevents age-related failure in beige adipogenesis by controlling ER stress via NAMPT, improving energy expenditure and glucose tolerance in mice.

Lymphotoxin-β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

This study shows that mechanically stimulated osteocytes release extracellular vesicles containing microRNAs that inhibit NSCLC cell proliferation and bone metastasis progression.

Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions

This study uses 3D imaging and genomic analysis to show that human pancreatic precancerous lesions (PanINs) are highly multifocal and genetically heterogeneous.

Structural insights into transcription activation mechanism of the global regulator GlnR from actinobacteria

This paper reports the crystal and cryo-EM structures of GlnR-DNA and GlnR-TAC complexes, revealing the transcription activation mechanism of GlnR in actinobacteria.

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

This study shows that inhibiting PDHK reduces NLRP3 inflammasome activation in macrophages, decreasing inflammation and tissue damage.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

Evaluation of Renal Markers in Systemic Autoimmune Diseases

This study examines renal markers in autoimmune diseases, finding that autoantibodies significantly affect marker levels and are more frequent in severe renal damage.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase

This study reports cryo-EM structures of human enteropeptidase in multiple states, revealing its activation mechanism and substrate recognition process.

Spike Protein Targeting "Nano-Glue" that Captures and Promotes SARS-CoV-2 Elimination

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

A versatile resource of 1500 diverse wild and cultivated soybean genomes for post-genomics research

The paper develops a genomic resource of 1,500 soybean genomes with 32 million SNPs to enable post-genomic research and applications like QTL discovery and trait allele identification.

A critical role of stable grain filling rate in maximizing rice yield revealed by whole plant carbon nitrogen interaction modeling

This study develops a whole-plant carbon nitrogen interaction model to show that a stable grain filling rate from flowering to harvest maximizes rice yield, validated in high-yielding cultivars.

Intraspecific genetic variation in anesthesia success in a New Zealand freshwater snail

The paper shows genetic variation in menthol anesthesia success among New Zealand freshwater snails, highlighting the need for diverse genetic backgrounds in biomedical research.

Single-cell RNA-seq data reveals TNBC tumor heterogeneity through characterizing subclone compositions and proportions

The paper uses single-cell RNA-seq data to identify subclonal compositions in TNBC and links them to survival outcomes and immune microenvironment diversity.

Synergistic effect: a common theme in mixed-species litter decomposition

The paper analyzes non-additive effects in mixed-species litter decomposition, finding synergistic and antagonistic effects under different conditions.

Breeding of a high-yield strain for commercial cultivation by crossing Pholiota adiposa and P. limonella

The paper crosses Pholiota adiposa and P. limonella to develop a high-yield hybrid strain for commercial cultivation.

The differential distribution of bacteria between cancerous and noncancerous ovarian tissues in situ

This study compares bacterial composition and functional differences between cancerous and noncancerous ovarian tissues using 16S rRNA sequencing and metagenomic predictions.

Assessment of gibberellin (GA4+7) mediated changes on grain filling, hormonal behaviour and antioxidants in high-density maize (Zea Mays L.)

This study evaluates the effects of GA4+7 application on maize grain filling, hormone levels, and antioxidants under different treatment methods, finding that 60 mg L-1 GA4+7 improves grain filling and delays leaf senescence.