Mismatch repair deficiency is not sufficient to increase tumor immunogenicity
P. M. K. Westcott, F. Muyas, O. Smith, H. Hauck, N. J. Sacks, Z. A. Ely, A. M. Jaeger, W. M. Rideout, A. Bhutkar, D. Zhang, M. C. Beytagh, D. A. Canner, R. T. Bronson, S. Naranjo, A. Jin, , T. Jacks
This study shows that MMRd in mouse tumor models does not increase immunogenicity or ICB response, due to intratumoral heterogeneity.
bioRxiv · Aug 24, 2021 · PreprintCancer Biology