Author

I. Cortes-Ciriano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 7 Cell Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 8 Assay:whole-genome sequencing· 7 Approach:statistical model· 6 Research Focus:cancer & tumor microenvironment· 5 Research Focus:differential expression· 5 Approach:experimental assay· 5 Research Focus:gene regulatory network inference· 4 Assay:bulk RNA-seq· 3

Frequent Co-Authors

F. Muyas· 4 shared A. Guyer· 2 shared A. M. Flanagan· 2 shared A. Mazzagatti· 2 shared E. G. Maurais· 2 shared J. Espejo Valle-Inclan· 2 shared M. D. Young· 2 shared M. Kalyva· 2 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersCancer Biology

F. Muyas

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Mechanisms underpinning osteosarcoma genome complexity and evolution

J. Espejo Valle-Inclan, S. De Noon, K. Trevers, H. Elrick, M. Tanguy, T. Butters, F. Muyas, F. Amary, R. Tirabosco, A. Giess, A. Sosinky, G. Elgar, A. M. Flanagan, I. Cortes-Ciriano

This study identifies chromothripsis and a novel LTA chromothripsis mechanism driving genome complexity and evolution in osteosarcoma, with prognostic implications for high-grade tumors.

bioRxiv · Dec 29, 2023 · PreprintCancer Biology

Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors

Q. Hu, J. Espejo Valle-Inclan, R. Dahiya, A. Guyer, A. Mazzagatti, E. G. Maurais, J. L. Engel, I. Cortes-Ciriano, P. Ly

This study shows that non-homologous end joining (NHEJ) is the main pathway causing complex genomic rearrangements during chromothripsis from mitotic errors.

bioRxiv · Aug 10, 2023 · PreprintCell Biology

Mitotic clustering of pulverized chromosomes from micronuclei

Y.-F. Lin, J. E. Valle-Inclan, A. Mazzagatti, Q. Hu, E. G. Maurais, A. Guyer, J. T. Sanders, J. Engel, G. Nguyen, D. Bronder, S. F. Bakhoum, I. Cortes-Ciriano, P. Ly

This study shows that acentric chromosome fragments from micronuclei cluster during mitosis, leading to biased inheritance and balanced chromothripsis in cancer.

Nature · Jun 29, 2023Peer-reviewedCell Biology

Transcriptional signals of dedifferentiation in human cancer

G. Kildisiute, M. Kalyva, R. Elmentaite, S. van Dongen, C. Thevanesan, A. Piapi, K. Ambridge, E. Prigmore, M. Haniffa, S. A. Teichmann, K. Straathof, I. Cortes-Ciriano, S. Behjati, M. D. Young

This study examines dedifferentiation in cancer using single-cell atlases, finding that adult cancers do not revert to an embryonic state but retain foetal signals, while childhood cancers show universal foetal state features.

bioRxiv · Nov 28, 2022 · PreprintCancer Biology

Genomic patterns of malignant peripheral nerve sheath tumour (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNA

I. Cortes-Ciriano, C. D. Steele, K. G. Piculell, A. Al-Ibraheemi, V. Eulo, M. M. Bui, A. Chatzipli, B. C. Dickson, D. C. Borcherding, A. Feber, A. Galor, J. Hart, K. B. Jones, J. T. Jordan, R. H. Kim, , D. T. Miller

This study identifies genomic patterns in MPNST evolution linked to clinical outcomes and shows these patterns are detectable in cell-free DNA.

bioRxiv · May 3, 2022 · PreprintCancer Biology

Profilin 1 deficiency drives mitotic defects and impairs genome stability

F. Scotto di Carlo, S. Russo, F. Muyas, M. Mangini, L. Pazzaglia, F. Biamonte, A. C. De Luca, K. Scotlandi, I. Cortes-Ciriano, F. Gianfrancesco

This study shows that Profilin 1 deficiency causes mitotic defects and genome instability in cancer cells.

bioRxiv · Feb 1, 2022Cell Biology

Clonal diversification and histogenesis of malignant germ cell tumours

T. R. W. Oliver, L. Chappell, R. Sanghvi, L. Deighton, N. Ansari-Pour, S. Dentro, M. D. Young, T. H. H. Coorens, H. Jung, T. M. Butler, M. D. C. Neville, D. Leongamornlert, M. A. Sanders, Y. Hooks, A. Cagan, , S. Behjati

This study analyzes the genome and transcriptome of 547 GCT histological units to explore clonal diversification and histogenesis, finding unifying genomic and transcriptional features across GCTs.

bioRxiv · Feb 1, 2022Cancer Biology

The ALT pathway generates telomere fusions that can be detected in the blood of cancer patients

F. Muyas, M. J. Gomez Rodriguez, I. Cortes-Ciriano, I. Flores

The paper identifies telomere fusions as a genomic signature of the ALT pathway in cancer, detectable in blood for early cancer detection.

bioRxiv · Jan 25, 2022Cancer Biology

Mismatch repair deficiency is not sufficient to increase tumor immunogenicity

P. M. K. Westcott, F. Muyas, O. Smith, H. Hauck, N. J. Sacks, Z. A. Ely, A. M. Jaeger, W. M. Rideout, A. Bhutkar, D. Zhang, M. C. Beytagh, D. A. Canner, R. T. Bronson, S. Naranjo, A. Jin, , T. Jacks

This study shows that MMRd in mouse tumor models does not increase immunogenicity or ICB response, due to intratumoral heterogeneity.

bioRxiv · Aug 24, 2021 · PreprintCancer Biology

Reconstructing the lineage histories and differentiation trajectories of individual cancer cells in JAK2-mutant myeloproliferative neoplasms

D. Van Egeren, J. Escabi, M. Nguyen, S. Liu, C. R. Reilly, S. Patel, B. Kamaz, M. Kalyva, D. J. DeAngelo, I. Galinsky, M. Wadleigh, E. S. Winer, M. R. Luskin, R. M. Stone, J. S. Garcia, , S. Hormoz

This study reconstructs the lineage histories and differentiation trajectories of JAK2-mutant HSCs in MPN patients, finding the mutation occurs decades before diagnosis and drives exponential growth of mutated HSC populations.

bioRxiv · Aug 24, 2020Cancer Biology