Structure and mechanism of TRAPPIII-mediated Rab1 activation
A. M. N. Joiner, B. P. Phillips, K. Yugandhar, E. J. Sanford, M. B. Smolka, H. Yu, E. A. Miller, J. C. Fromme
This study determines the cryo-EM structure of the yeast TRAPPIII complex bound to Rab1/Ypt1, revealing that Trs85 anchors the complex to membranes via an amphipathic helix to activate Rab1.
bioRxiv · Oct 8, 2020 · PreprintCell Biology