E. A. Miller

NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni

This study identifies NLRP3 and AIM2 inflammasomes as key drivers of pathogenic Th17 responses in Schistosoma mansoni infection, showing their role in promoting inflammation and their counteraction by the IFN-I pathway.

Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes

This study uses cryo-electron tomography to show COPII forms spherical vesicles by binding cargo on native membranes, revealing its structure and how it generates membrane curvature.

Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma

This study identifies tumor-specific CD4 T cells as regulators of monocyte differentiation into antitumor macrophages in pancreatic ductal adenocarcinoma, showing their role in suppressing tumor growth.

Habitat use differences mediate population threat exposure in white sturgeon

The paper examines habitat use differences in white sturgeon across life stages and links these patterns to population threats like angler pressure and red tide exposure.

A molecular mechanism for membrane chaperoning by a late embryogenesis abundant protein

This paper identifies HeLEA1, a tardigrade LEA protein that acts as a mitochondrial membrane chaperone, improving stress tolerance in yeast by stabilizing lipid packing and reducing surface tension.

Supramolecular architecture of the ER-mitochondria encounter structure in its native environment

The paper determines the supramolecular architecture of the ERMES complex in yeast using integrative structural biology methods, revealing its role in lipid transfer between ER and mitochondria.

Ultrastructure of COPII vesicle formation characterised by correlative light and electron microscopy.

This study uses correlative light and electron microscopy to examine COPII coat structure and its role in membrane remodeling during protein transport in yeast cells.

Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export.

The paper inhibits protein secretion by disrupting receptor-coat interactions, specifically targeting PCSK9 and other SURF4 clients without affecting other secreted proteins.

Structures of core eukaryotic protein complexes

The paper uses coevolution analysis and deep learning to model core eukaryotic protein complexes in yeast, identifying 104 new assemblies and structurally characterizing 608 previously unknown complexes.

Structure and mechanism of TRAPPIII-mediated Rab1 activation

This study determines the cryo-EM structure of the yeast TRAPPIII complex bound to Rab1/Ypt1, revealing that Trs85 anchors the complex to membranes via an amphipathic helix to activate Rab1.

Structure of the complete, membrane-assembled COPII coat reveals a complex interaction network.

This study reveals the structure of the complete, membrane-assembled COPII coat and identifies key interactions that drive membrane curvature and coat adaptability.

The architecture of EMC reveals a path for membrane protein insertion

The paper determines the structure of the EMC complex and identifies a pathway for membrane protein insertion by analyzing its architecture and interactions.

A multivalent fuzzy interface drives reversible COPII coat assembly.

The paper investigates how the COPII coat assembles and disassembles through multivalent interactions, revealing design principles for reversible vesicle formation.

Cargo crowding drives sorting stringency in COPII vesicles

The paper shows that cargo crowding in COPII vesicles enhances sorting stringency by restricting bulk flow, improving ER quality control.

An in vitro vesicle formation assay to analyze protein sorting in the secretory transport pathway

The paper develops an in vitro vesicle formation assay to identify proteins involved in cargo sorting and trafficking, revealing novel regulators like FAM84B and PRRC1.

Gatekeeper helix activates Golgi SM protein Sly1 and directly mediates close-range vesicle tethering

The paper identifies a gatekeeper helix in Sly1 that binds membranes to relieve autoinhibition and mediate close-range vesicle tethering in the early secretory pathway.

Emergence of a novel Salmonella enterica serotype Reading clone is linked to its expansion in commercial turkey production, resulting in unanticipated human illness in North America

This study identifies a novel Salmonella enterica serotype Reading clone linked to human outbreaks and commercial turkey production in North America through genomic analysis.

Robust and replicable measurement for prepulse inhibition of the acoustic startle response

This paper develops a novel model to measure prepulse inhibition (PPI) in rats, revealing consistent results and sex differences, and proposes a reliable method for future studies.

Rod-shaped tricalbins contribute to PM asymmetry at curved ER-PM contact sites

The paper investigates how tricalbins in budding yeast regulate PM asymmetry at ER-PM contact sites through structural and genetic analyses.