Epistasis and physico-chemical constraints contribute to spatial clustering of amino acid substitutions in protein evolution.
A. M. Taverner, L. J. Blaine, P. Andolfatto
The paper examines spatial clustering of amino acid substitutions across species and finds that epistasis and convergent evolution, rather than thermodynamic constraints, drive this pattern.
bioRxiv · Aug 5, 2020 · PreprintEvolutionary Biology