P. Andolfatto

Patterns of recombination in snakes reveal a tug of war between PRDM9 and promoter-like features

The study analyzes recombination patterns in corn snakes to show that both PRDM9 and promoter-like features influence recombination, revealing a competitive interaction between these mechanisms.

Predatory fireflies and their toxic firefly prey have evolved distinct toxin resistancestrategies.

This study shows that predatory fireflies and their toxic prey have evolved distinct toxin resistance strategies through gene duplication and neofunctionalization.

The 3-Dimensional Genome Drives the Evolution of Asymmetric Gene Duplicates via Enhancer Capture-Divergence

This paper shows that enhancer capture-divergence (ECD) is a significant evolutionary mechanism for asymmetric, distally duplicated genes, using Drosophila HP6/Umbrea as an example.

Epistatic effects between amino acid insertions and substitutions mediate toxin-resistance of vertebrate Na+,K+-ATPases

The paper shows how amino acid insertions and substitutions in Na+,K+-ATPase affect toxin resistance in different vertebrate lineages through epistatic interactions.

Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence

The paper investigates how intramolecular epistasis affects the evolution of CTS-resistant Na,K-ATPases, finding that resistance substitutions have pleiotropic effects independent of sequence divergence.

Diet unmasks genetic variants that regulate lifespan in outbred Drosophila

This study identifies lifespan-altering genetic variants in Drosophila under different diets, showing context-dependent effects and genotype-by-environment interactions.

Epistasis and physico-chemical constraints contribute to spatial clustering of amino acid substitutions in protein evolution.

The paper examines spatial clustering of amino acid substitutions across species and finds that epistasis and convergent evolution, rather than thermodynamic constraints, drive this pattern.

Concerted evolution reveals co-adapted amino acid substitutions in Na+K+-ATPase of frogs that prey on toxic toads

The paper shows that selection maintains adaptive division-of-labor between tandem duplicates of ATP1A1 in frogs, countering gene conversion to confer toxin resistance.

The genetic architecture of the sexually selected sword ornament and its evolution in hybrid populations

The paper investigates the genetic architecture of a sexually selected sword ornament in swordtail fish, identifying a major QTL and candidate genes, and finding evidence of selection against the trait in hybrid populations.

Natural hybridization reveals incompatible alleles that cause melanoma in swordtail fish

Using a combination of mapping approaches, we identify interacting genes that lead to melanoma in hybrids and characterize their effects in natural hybrid populations.

Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo.

The paper investigates how adaptive substitutions in Na+,K+-ATPase affect cardiac glycoside insensitivity in insects, revealing epistatic interactions that constrain evolution.

Predictability in the evolution of Orthopteran cardenolide insensitivity

This study examines the evolution of cardenolide insensitivity in Orthoptera, finding predictable patterns similar to other insect orders and identifying sites under positive selection.

Natural selection interacts with the local recombination rate to shape the evolution of hybrid genomes

The persistence of hybrid ancestry is predictable from local recombination rates in three replicate hybrid populations and in humans.